quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities

the heterocyclic compounds have a great importance in medicinal chemistry. one of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-hiv, anticancer and analgesic activities. this skeleton is an important pharmacophore considered as a privileged structure. this review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.